Assembling yeast chromosomes like Legos has a serious goal: safe lab-made creatures
Jef Boeke really, really wanted to avoid giving his yeast cells a “teeny weeny” chromosome. And not because the other yeast would make fun of them.He was well into his trailblazing project to “write” the first complete genome (“reading,” or sequencing, genomes being so 2000s), with the single-celled organism baker’s yeast the test case. As part of that Synthetic Yeast 2.0 scheme, he and his team had decided to fuse the yeast’s shortest chromosome with a longer one, in order to avoid the teeny-weeny problem — he worried that very short synthetic chromosomes might not be viable. Then a colleague asked, why stop at one? Why not see how many of yeast’s 16 distinct chromosomes you can fuse? [email protected] GET STARTED @sxbegle What’s included? By Sharon Begley Aug. 1, 2018 Reprints Unlock this article by subscribing to STAT+ and enjoy your first 30 days free! GET STARTED STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. What is it? In the Lab Log In | Learn More Senior Writer, Science and Discovery (1956-2021) Sharon covered science and discovery. Assembling yeast chromosomes like Legos has a serious goal: safe lab-made creatures Sharon Begley Tags biotechnologyCRISPRgeneticsresearch About the Author Reprints A microscope image of baker’s yeast. Dr. Gerhard Wanner/ZEISS Microscopy Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr.