June 16

New drugs entering Canada at steady rate over past 5 years

first_imgNew drugs entering Canada at steady rate over past 5 years From: Patented Medicine Prices Review Board CanadaCanada still among top 10 OECD countries in terms of access to new drugsThe latest edition of the Patented Medicine Prices Review Board (PMPRB) Meds Entry Watch reports that 40 new-to-Canada medicines were approved for market in 2018, of which 22 had reported sales by the end of 2019. This is in line with the annual rate of approximately nine new approvals per quarter since 2015, a trend that continued steadily into 2019.Internationally, 51 new drugs were first approved in the US, Europe, and Canada in 2018, of which more than two thirds were high-cost and over 60% were treatments for rare diseases. Four of the five top-selling new medicines were approved in Canada in the same year, including the antiviral drug bictegravir (Biktarvy), which alone accounted for over half of total sales for the 51 new medicines by the end of 2019.This report, produced through the National Prescription Drug Utilization Information System (NPDUIS) research initiative, is the fifth edition in the annual Meds Entry Watch series, which provides the latest information on new medicines entering Canadian and international markets.Quick factsIn 2018, Health Canada approved 40 new-to-Canada medicines, of which 22 had reported sales by Q4-2019, accounting for 1.6% of the total Canadian pharmaceutical market. On average, international prices for these medicines were 19% lower than the prices paid by Canadians.51 new medicines were approved internationally in 2018, of which over 60% had an orphan designation from the FDA and/or the EMA while more than 30% were indicated for the treatment of cancer.Health Canada had approved 20 of the 51 new medicines by the end of 2019, of which nine had recorded sales in Canada, placing Canada ninth in the OECD and in line with the PMPRB11 comparator countries, most of which have lower average patented medicine prices.Over two thirds of the new medicines approved in 2018 were high-cost: 13 oncology medicines had costs exceeding $5,000 per 28-day cycle and 21 non-oncology medicines had annual costs exceeding $10,000.Of the total new medicines approved internationally between 2015 and 2018, 38% had Canadian sales by the end of 2019. This group of medicines accounted for 87% of all new medicine sales in the OECD in Q4-2019, indicating that the higher-selling medicines continue to be among those approved and sold in Canada.47 new medicines received market authorization in 2019, of which 16 were approved in Canada by Q3-2020. In total, 40% (19) of the 2019 new medicines were orphan-designated while just under a quarter were oncology treatments. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:antiviral, Canada, cancer, drug, Europe, FDA, Government, health, market, medicine, OECD, oncology, research, sales, treatment, U.S.last_img read more

June 4

Kenya 4G licence attracts 10 bids

first_imgHome Kenya 4G licence attracts 10 bids Previous ArticleInterview: UN FoundationNext ArticleIntel considers Broadcom takeover Bangladesh 4G auction raises $898M AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 12 MAR 2018 Ten companies applied for 4G spectrum licences in Kenya, with the intention of using them to offer high-speed internet and mobile phone services, Business Daily reported.The Communications Authority of Kenya (CA) said the applications by interested parties, which are comprised of two consortiums of five companies each, were submitted in December 2017 and are still under evaluation. The consortiums are seeking spectrum in the 700MHz frequency band which can be used for 4G and was freed up when Kenya migrated to digital television.CA director general Francis Wangusi said the regulator’s board made a decision to have two consortiums and give them spectrum on trial for one year: “Then if they are successful, they pay the $25 million (spectrum fee),” he stated.Wangusi explained this was done because there is limited spectrum and “if we were to give to one, then the others might cry foul”.Tier-two targetsThe 700MHz spectrum band is divided into three blocks, one of which was assigned to Jamii Telecom in 2017, leaving two blocks remaining. The bid is closed off to the country’s top operators – Safaricom, Airtel and Telkom Kenya – as they already have spectrum in the 800MHz band which they are using for 4G.While the ten interested companies have not been named, CA lists Wananchi Group, Liquid Telecom, iWay Africa, and AccessKenya Group among the tier two providers. The Unified Licensing Framework allows such companies to provide mobile services, but they have yet to be allocated the necessary spectrum.Consortium members can choose to either have the spectrum issued to one of the five members, or jointly invest in a special purpose vehicle which will run the network on their behalf, Business Daily explained.In the case of the former the chosen member would roll out the network and lease it out to the rest of the consortium.Challenges the consortiums are likely to face include the lack of a variety of cheap devices compatible with the 700MHz band, the newspaper reported. Jamii Telecom, which launched 4G services in 2017, is facing this issue. The need to invest massively in infrastructure and the inability to serve customers whose devices are still on 2G or 3G could also prove to be hurdles.The CA said there are plans to allocate additional bands of spectrum to tier two operators in the future and it wants to encourage infrastructure sharing. Related Author Safaricom puts Kenya on the 5G map Saleha Riaz Verizon details DSS progress Saleha joined Mobile World Live in October 2014 as a reporter and works across all e-newsletters – creating content, writing blogs and reports as well as conducting feature interviews…More Read more 4GKenya Tags last_img read more

May 27

Legislature Delivering on Jobs Bills

first_imgWhen the Legislature came to town in early January, it seemed clear that jobs would be the No. 1 issue of the session. Now that the Legislature is past the halfway point, this is a good time to reflect on how the people’s branch is doing on that key issue.In just two months, the Legislature made good progress on delivering positive legislation targeted to help with the creation of good-paying jobs. Sure, there are some sensational bills on other issues that get a lot of media attention, but there are also several bills that encourage businesses to expand, hire new workers and grow our state’s economy.First and foremost, the Legislature has made progress on addressing one of the top job-killing problems in the state: workers’ compensation costs. House Bill 334 (introduced by Scott Reichner, R-Bigfork) has passed out of the House and awaits action by the Senate. Legislators in both parties are working together to develop a compromise bill that can get signed into law. If we want Montana to be a great place to work and do business, we must reform our costly workers’ comp system.Second, after hearing from Montana’s entrepreneurs on Jan. 8, the Legislature has moved forward two bills aimed at ensuring government doesn’t burden small businesses with unnecessary regulation or new laws. House Bill 100 (Gordon Vance, R-Bozeman) and Senate Bill 201 (Edward Walker, R-Billings) say state government needs to look at impacts to small businesses before new laws are passed during the session or when new rules are written during the interim.In addition, bills are moving through the process to address employer concerns about the use of medical marijuana in the workplace. Much attention has been placed on the House’s vote to repeal the law, but there are several more bills aimed at increasing regulation and oversight for medical marijuana. House Bill 43 (Gary MacLaren, R-Victor) clarifies the law to ensure that employers have the right to make important business decisions regarding an employee’s use of medical marijuana.Another area that has received attention is the issue of legal reform. When Montana improves its legal climate, it also improves its business climate. A number of tort reform bills are moving forward in the 62nd Legislature: reforms to pre/post-judgment interest rates, establishment of appeal bond caps, and medical malpractice reform to bring down the cost of healthcare. In response to the overwhelming support for increased responsible resource development, the Senate has acted on two bills that will create jobs and add more revenue in the future for schools. Senate Bill 233 (Jim Keane, D-Butte) and Senate Bill 317 (Chas Vincent, R-Libby) attempt to remove the ability of obstructionist environmentalists from filing frivolous lawsuits to block responsible development. If Montana were to reach its full potential in this arena, we would no longer have to deal with budget cuts and finding money for schools.The second half of the session is often reserved more for budget and tax issues, so we look forward to working with legislators in both parties to reduce the business equipment tax, make the tax code simpler for businesses and individuals, and keep other taxes low during this recovery.These are just a few examples of the good pro-jobs bills and ideas moving forward in Helena. We are encouraged by the progress we see on many key proposals this session that will help businesses create jobs and grow our state’s economy. While there may be proposals that stray from the top issue of job creation, know that the Legislature is also moving forward good legislation as well. Contact your legislator soon to encourage them to finish the job and help get Montanans back to work.Jon Bennion is the Government Relations Director for the Montana Chamber of Commerce. Stay Connected with the Daily Roundup. Sign up for our newsletter and get the best of the Beacon delivered every day to your inbox. Emaillast_img read more

May 12

People of the Year 2018: Annapurna Interactive

first_imgPeople of the Year 2018: Annapurna InteractiveThe acclaimed indie publisher continues to make its mark on the industry – despite its efforts to stay behind the scenesJames BatchelorEditor-in-ChiefTuesday 11th December 2018Share this article Recommend Tweet ShareIt’s almost comical how many publishers have entered the market in the past few years, bringing to mind some cartoonish gold rush as new players compete to sign the next big indie hit.While some select a niche on which to focus, many seem to take a scattergun approach when it comes to filling their portfolio, signing games across a variety of genres and platforms in the hopes that one (or, ideally, more) will skyrocket in order to counteract any disappointments.And then there’s Annapurna Interactive, a highly selective boutique publisher that has thus far only released a handful of titles per year.”They tend to be beautiful experiences that push and prod at the boundaries of what games can be” Ken Wong, MountainsTwo years since the offshoot of Annapurna Pictures emerged, the company has already made a lasting impression on the industry. While the Hollywood brand behind award-winning flicks such as Zero Dark Thirty and American Hustle was always going to turn heads, whether it could translate that success to the world of video games was much more questionable — but no more.The firm has released just three new titles this year, all of them acclaimed: Florence, the debut title from Ken Wong’s new studio Mountains, Ben Esposito’s wacky indie game Donut County, and the hotly anticipated RPG Ashen. Plus, it brought Gone Home to Nintendo Switch around the game’s fifth anniversary, continuing its work of bringing established indie hits to new audiences.And it’s still riding high on its 2017 releases, with both Gorogoa and What Remains of Edith Finch winning BAFTAs earlier this year — the latter taking the highest honour, Game of the Year. This year’s cohort is already racking up its own wins in the Apple and Google Game of the Year Awards, with Florence also taking home a gong from The Game Awards.Annapurna’s future line-up also had a strong presence at the latter, with Giant Squid’s The Pathless and Simogo’s Sayonara Wild Hearts just two of the big reveals of the night. Simultaneously, three of the company’s titles appeared among the launch line-up for the Epic Games Store, making Annapurna (currently) the non-Epic publisher with the biggest library on the new marketplace.In short, there’s been no escaping Annapurna Interactive in 2018.There aren’t many publishers who would choose a title about remote-controlled holes and trash-stealing raccoons as one of just three new releases for the yearAs many a mildly frustrated journalist knows, the publisher itself rarely gives interviews, instead preferring for “the games to speak for themselves”. So in the face of such modesty, we have instead turned to the developers it works with to discuss what makes Annapurna so special.Ken Wong, Mountains”The thing to know about Annapurna is that they primarily look for people, not projects,” says Ken Wong, lead designer of Monument Valley and director of Florence. “The various team members have been around the industry to know that games evolve and change during development. “A good pitch isn’t as important to them as people they want to work with, people who they feel they can have genuine creative discussions with. They also know they need to grow together as a team and learn from their mistakes, so they’ve been careful about how many projects to take on at a time.”Derek Bradley, game director at Ashen developer A44, adds: “They are a very creative, design-driven team who aren’t afraid to take risks. I believe Annapurna sign games that they truly enjoy from teams they believe in.”Much like Devolver Digital, it’s hard to pinpoint the exact aspect or quality that links Annapurna’s titles together — but the link is undoubtedly there. From the aforementioned games to upcoming titles like The Artful Escape, you can almost tell an Annapurna game by sight. “They are a very creative, design-driven team who aren’t afraid to take risks… signing games that they truly enjoy from teams they believe in” Derek Bradley, A44Perhaps it’s the artistry. While Florence (a personal favourite) is not mechanically complex, the way it weaves mini-games into a hugely relatable story of love and life, plus its striking hand-drawn style, elevates it above other titles.Or perhaps it’s the inventiveness. Donut County may not have a high-brow concept — you play a hole in the ground, controlled by a trash-stealing raccoon, gobbling up everything in your path — but it’s a premise that proved to be compelling enough that mobile leader Voodoo lifted it wholesale for its own chart-topping ends.Wong suggests that there’s “a certain romanticism” that links Annapurna’s games: “They tend to be beautiful experiences that push and prod at the boundaries of what games can be. At the same time, each game has a unique voice that shines through, something of a worldview or a philosophy.”Bradley says: “I honestly don’t think that there is a particular theme in the games you are likely to see from Annapurna in the future, outside of the games they publish being extremely creative while also being high quality.”Both studios have nothing but praise for Annapurna when it comes to the working relationship. In fact, Wong suggests that just as no two Annapurna titles are the same, the publisher also avoids a one-size-fits-all approach to liaising with developers.Related JobsSenior Game Designer – UE4 – AAA United Kingdom Amiqus GamesProgrammer – REMOTE – work with industry veterans! North West Amiqus GamesJunior Video Editor – GLOBAL publisher United Kingdom Amiqus GamesDiscover more jobs in games “I think they adapt themselves to the needs of each developer they work with,” he says. “In our case I think what we needed most was patience, as we went through prototype after prototype. We needed time to gel as a new team and discover the right project. I appreciated that they offered feedback but it was always up to us what to do with it. They supported us in making the game we wanted, and I think that’s why it turned out to be so special.”While its pace of release may be slower than other indie publishers, Annapurna shows no signs of losing momentum when it comes to acclaimed and anticipated titles. In addition to the next games from the teams behind Abzu and Device 6, the publisher is also up to the release of Telling Lies (the spiritual successor to Sam Barlow’s Her Story), indie open world title Outer Wilds, Wattam (from the mind of Katamari Damacy designer Keita Takahashi), and the complete edition of episodic point-and-click adventure Kentucky Route Zero.In short, there will still be no escaping Annapurna Interactive.Celebrating employer excellence in the video games industry8th July 2021Submit your company Sign up for The Publishing & Retail newsletter and get the best of GamesIndustry.biz in your inbox. Enter your email addressMore storiesEA leans on Apex Legends and live services in fourth quarterQ4 and full year revenues close to flat and profits take a tumble, but publisher’s bookings still up double-digitsBy Brendan Sinclair 3 hours agoUbisoft posts record sales yet again, delays Skull & Bones yet againPublisher moves away from target of 3-4 premium AAA titles a year, wants to build free-to-play “to be trending toward AAA ambitions over the long term”By Brendan Sinclair 7 hours agoLatest comments Sign in to contributeEmail addressPasswordSign in Need an account? Register now.last_img read more

November 19

Study finds association between teen sleep patterns and alcohol or marijuana use

first_imgShare “Our findings suggest that sleep issues are independently associated with alcohol and marijuana use for teens, not just a marker for other risk factors, such as depression,” said Wendy Troxel, the study’s lead author and a behavioral scientist at RAND, a nonprofit research organization. “Better understanding of the association between sleep and substance use is important for parents, schools and others involved in alcohol and drug prevention efforts for this age group.”The teenagers in the study were originally recruited from 16 middle schools across three school districts in Southern California. There was a total of 2,539 teens who self-reported their total sleep time and bedtime via a single assessment Web survey, as well as alcohol or marijuana use, when the teens were in high school. The surveys were completed between May 2013 and April 2014.The research team cautions that although the findings show an association between sleep and the use of alcohol and marijuana, it is not possible to determine cause from effect without additional research. The RAND team is currently collecting long-term research data to study whether sleep problems predict or lead to the onset of alcohol and/or marijuana use in teens.Regarding sleep more generally among adolescents, RAND researchers suggest that both individual-level prevention strategies as well as policy-level strategies are needed to improve adolescent sleep. For example, policy-level strategies include recent efforts to delay high school start times, an approach that has been recommended by the American Academy of Pediatrics and other professional organizations. Pinterest Share on Facebook Share on Twittercenter_img LinkedIn Adolescents who sleep less or stay up later are significantly more likely to have used alcohol and marijuana over the past month when compared to their peers who report better sleep patterns, according to a new RAND Corporation study.Studying adolescents in Southern California, researchers found that the association between sleep and alcohol/marijuana use was consistent even after controlling for other known risk factors, such as depression.The findings, published online by the journal Sleep Health, were generally consistent across racial and ethnic groups. Emaillast_img read more

September 16

Clippers leave winning runs on base, fall to 5-6 after Sunday loss to Galion Graders

first_img FOX Sports: Stream live NFL, College Footbal… Share Share Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Displayed poorly Add Comments (Max 320 characters) Add Comments (Max 320 characters) Add Comments (Max 320 characters) ENDS IN Not relevant Report a problem This item is… Ads by Amazon × × Other Inappropriate / Offensive Displayed poorly Inappropriate / Offensive Other Other Fox Sports Go Report a problem This item is… 50PC Disposable Face MàSc/Mack Anti-Dust … Displayed poorly Not relevant ENDS IN Inappropriate / Offensive Thank you! This will help us improve your ad experience. We will try not to show you such ads again. (7802) Bestseller Displayed poorly × 0 Add Comments (Max 320 characters) Twelve DEAL OF THE DAY The Sports Gene: Inside the Science of Extr… Displayed poorly Report a problem This item is… $15.29$17.99 × Add Comments (Max 320 characters) Report a problem This item is… Bestseller Not relevant Carsie Walker delivers the pitch for Muskegon. Photo/Jason Goorman $0.00 Inappropriate / Offensive (31628) Mail (17612) ENDS IN DEAL OF THE DAY Muskegon first baseman No. 25 Brian Martin takes a throw on the late pickoff move. Photo/Jason Goorman × Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Inappropriate / Offensive Add Comments (Max 320 characters) Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Displayed poorly Displayed poorly × (34271) (822) Other Thank you! This will help us improve your ad experience. We will try not to show you such ads again. DEAL OF THE DAY ENDS IN Not relevant Displayed poorly DEAL OF THE DAY DEAL OF THE DAY ENDS IN Shop Now Not relevant By Dave HartLocalSportsJournal.comMUSKEGON – The Muskegon Clippers had chances to complete a comeback victory on Father’s Day at Marsh Field, but the most important base runners never crossed the plate.Cooper Peterson rounds third base as coach Walt Gawkowski waves him in for the Clippers first run of the game. Photo/Jason GoormanThe Clippers left 10 runners on base throughout the contest, yet still managed to put the tying run at the plate during the ninth inning.But Muskegon couldn’t quite get it done, falling to the Galion Graders 7-5 on Sunday in the finale of the three-game home series.The Clippers are now 5-6 on the season, good for fifth place in the Northern Division of the GLSCBL. They will continue their home stand on Tuesday night against the Cincinnati Steam. First pitch is set for 7:05 p.m.“We just were not too opportunistic tonight,” said Clippers manager Walt Gawkowski. “We had opportunities and we just couldn’t cash in. But it has been the same story where we are just falling behind and chasing teams. But we did battle back tonight. We didn’t play great baseball this weekend, and we are better than that.”The Graders jumped out to a 4-0 lead, scoring one run in the first inning and three in the third frame.Galion opened the scoring with a Bryce Ray RBI single, then added runs on RBIs by Thomas Stabb, Steven Deusanio and Sean McLaughlin.The Clippers finally scored in the bottom of the fourth inning on an RBI single from Ty Olejnik to cut the deficit to 4-1.Galion quickly responded with a two-run single from Deusanio to give the Graders a 6-1 advantage.Noah Hecht responded with a solo home run for the Clippers to cut the deficit to 6-2 in the sixth inning.The Clippers continued their comeback effort in the seventh inning with a two-run single by Tre Morris to make the score 6-4.The Graders responded with a run of their own in the eighth frame on an RBI single from Ryan Strittmather to give Galion a 7-4 lead.Muskegon closed out the scoring in the ninth inning on an RBI single by Morris. That brought the tying run to the plate with two outs. But Hecht closed out the contest with a groundout to the third baseman.Clippers pitcher Carsie Walker suffered the loss from the mound, allowing four runs on eight hits in 2 2/3 innings. DEAL OF THE DAY Bestseller Bestseller ENDS IN Thank you! This will help us improve your ad experience. We will try not to show you such ads again. DEAL OF THE DAY ENDS IN Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Add Comments (Max 320 characters) Other Ads by Amazon Bestseller Other Bestseller × $49.95 Not relevant Add Comments (Max 320 characters) Report a problem This item is… Nolan Bryant gets ready to lay down a tag at second base. Photo/Jason Goorman NBC Sports Inappropriate / Offensive (117) Other Inappropriate / Offensive Shares The League Inappropriate / Offensive $14.99$18.00 $0.00 MIRITY Women Racerback Sports Bra… Not relevant Not relevant $9.99 Report a problem This item is… Thank you! This will help us improve your ad experience. We will try not to show you such ads again. (657) Muskegon’s Austin Eifrid takes first base after getting hit by the pitch. Photo/Jason Goorman × ENDS IN Report a problem This item is… Other Bestseller $0.00 Bestseller (2) DEAL OF THE DAY Report a problem This item is… $37.99last_img read more